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[120] identified one of these non-opioid receptor targets as being adrenergic receptors, observing that three kappa opioid receptor agonists bound in the mid- to high-nanomolar range to alpha-1a adrenoceptors, one acting as a potent functional enhancer

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The biological plausibility of AOD9604’s cartilage-regenerating effects is further supported by insights from conditions such as acromegaly, where excess GH leads to abnormally thick cartilage due to elevated local IGF-1 production